Our lab is interested in understanding epigenetic regulation of transcription in the mammalian genome that governs development and related human diseases. For this purpose we use a variety of methods in molecular biology, genomics and bioinformatics. By combining “wet” lab and “dry” lab, we aim to further decipher the mechanisms underlying a number of key biological processes:
- Epigenetics regulation of stem cell pluripotency and cell differentiation;
- Epigenetic regulation of early animal development;
- The role of cis-regulatory elements such as enhancers and promoters and 3D genome architecture in transcription;
- Molecular mechanisms underlying human diseases linked to aberrant epigenetic regulation.